Built-in into the control system for the One-Pot
processors, Collette (part of GEA Pharma Systems group) has integrated
its granulation and drying process knowledge and experience to help operators
monitor and control the process easily. Depending on the automation and
reporting requirements, Collette can offer two different control systems both
of which provide the operator with all necessary process information in a clear
and easy to understand way.
Process Control
- OP/ PLC control system
This control system provides basic functionality and process
visualisation with data recording via a separate paperless recorder. It is
designed to be FDA 21 CFR Part 11 compliant and provides a basic level of
process automation with recipe control.
- Procoll Pro control system
This SCADA based control system provides a maximum level
of flexibility and functionality in terms of process visualisation, automation
and data recording. It is designed for integration with customer MES systems
for receiving and reporting GMP relevant data. The
system
is very much process orientated and guides using in-built intelligence the
creation of recipes and automatic processing. All process data
is stored in a
relational database. The system is fully
FDA 21 CFR Part 11 compliant and
provides features like
audit trail including reporting and configurable
graphs
for process values. This batch control system is designed according to
the S88.01 batch control standards.
Process Monitoring
A video camera installed in the head of the machine provides a
complete view into the process vessel. This is the ideal tool for state of the
art processing and gives the operator a clear indication of the product
behaviour and flow while the vessel is closed. Not only for product development
but also for production this feature provides a huge advantage for modern
integrated and
contained processing.
PAT
integration As well as the classical tools for
monitoring and controlling process like torque measurement for granulation
control, or temperature, pressure and energy input for the drying process,
Collette has developed innovative solutions for the integration of NIR (near
infrared) and FBRM (focused beam reflectance measurement) sensors into its
processes and the controls.
These advanced measurement
tools are used for the direct measurement of product quality parameters such as
moisture content, homogeneity of the mix, and particle size distribution,
providing control parameters for direct release of the
product.
GEA Pharma Systems (GPS) has joined forces with J&M
GmbH to create a compact and cleanable in-process optical probe for use in
powder processing equipment.
The result is the novel
Lighthouse Probe™, which can be used with a range of spectroscopic techniques,
including NIR and UV/vis, to overcome the traditional problem of product
sticking to observation windows.